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21.
Edwin A. Murillo 《应用聚合物科学杂志》2020,137(8):48386
Waterborne star-shaped styrene-alkyd resins (SSARs) were synthesized from a branched alkyd resin (AR) and styrene (St) by miniemulsion polymerization. SSARs are an environmentally friendly material. The ratio of AR to St for obtaining SSARs was as follows: 50:50 (SSAR1), 60:40 (SSAR2), 70:30 (SSAR3), and 80:20 (SSAR4). The conversion percentage was directly proportional to St used, and was higher than 94.0 %. Infrared analysis and protonic nuclear magnetic resonance revealed the reaction between AR and St. The synthesis process also leads to the formation of polystyrene and its concentration increases with the concentration of St. The values of the reacted double-bond fractions were higher than 17.80%. The SSARs drop size was bigger than the particle size. The miniemulsion colloidal stability was good at room temperature. The SSARs zeta potential was between −55 and −90 mV. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48386. 相似文献
22.
Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono‐ or disaccharides. Galactose, mannose, fucose, glucose, sialic acid, etc., are commonly used as powerful scaffolds installed on drug molecules for targeting specific tissues including brain, liver, and cancers, and as epitopes for enhancing the targeting of various vaccines. This review focuses on the influence of their structural variations, including changes in sugar type, substituent groups and their positions, as well as length of linker portion, on the targeting of drugs or their efficacy. Particular attention is paid to the targeting properties of mono‐ and disaccharides applied in drug design and discovery. 相似文献
23.
Dr. Mathieu Lalande Dr. Lucas Schwob Dr. Violaine Vizcaino Dr. Fabien Chirot Dr. Philippe Dugourd Dr. Thomas Schlathölter Dr. Jean-Christophe Poully 《Chembiochem : a European journal of chemical biology》2019,20(24):2972-2980
In this review, recent progress in understanding the direct effects of radiation on the structure and stability of collagen, the most abundant protein in the human body, and other proteins is surveyed. Special emphasis is placed on the triple-helical structure of collagen, as studied by means of collagen mimetic peptides. The emerging patterns are the dose dependence of radiation processes and their abundance, the crucial role of radicals in covalent-bond formation (crosslinking) or cleavage, and the influence of the radiation energy and nature. Future research should allow fundamental questions, such as charge transfer and fragmentation dynamics triggered by ionization, to be answered, as well as developing applications such as protein-based biomaterials, notably with properties controlled by irradiation. 相似文献
24.
Potential mGAT4 inhibitors derived from the lead substance (S)-SNAP-5114 have been synthesized and characterized for their inhibitory potency. Variations from the parent compound included the substitution of one of its aromatic 4-methoxy and 4-methoxyphenyl groups, respectively, with a more polar moiety, including a carboxylic acid, alcohol, nitrile, carboxamide, sulfonamide, aldehyde or ketone function, or amino acid partial structures. Furthermore, it was investigated how the substitution of more than one of the aromatic 4-methoxy groups affects the potency and selectivity of the resulting compounds. Among the synthesized test substances (S)-1-{2-[(4-formylphenyl)bis(4-methoxyphenyl)-methoxy]ethyl}piperidine-3-carboxylic acid, that features a carbaldehyde function in place of one of the aromatic 4-methoxy moieties of (S)-SNAP-5114, was found to have a pIC50 value of 5.89±0.07, hence constituting a slightly more potent mGAT4 inhibitor than the parent substance while showing comparable subtype selectivity. 相似文献
25.
This study explored adolescents’ opinions about how Internet use supports the achievement of their developmental tasks. Qualitative data were collected in focus groups interviews with 127 Italian Internet users (11–20) attending middle and high schools. Discussions were recorded, transcribed and analyzed using content analysis. Results showed that the Internet plays important functions in identity formation, personal autonomy, and relationships outside the family. It allows teens to develop their own interests, to identify with others and, at the same time, differentiate from others. The Internet is also an arena in which adolescents develop and practice autonomy. The Internet can be a source of conflict with parents, because of parents’ concerns about Internet use. However, the Internet can also be a meeting ground with parents. Finally, participants indicated the Internet is used to form close relationships with peers. Gender and age differences are discussed. Although the study is cross-sectional and relies only on adolescent report, findings illustrate how the conceptual framework of developmental goals may be helpful for understanding how the Internet can affect adolescents’ lives. 相似文献
26.
Using a comprehensive set of drop weight impact test data (h50) newly compiled from literature for 308 materials, a recent approach to predict impact sensitivities of nitro compounds is generalized to most explosive substances of interest. Compared to previous ones, this procedure is more thoroughly validated and exhibits a good predictive value. Furthermore, it yields new insight into the physical mechanisms involved, explaining for instance the unexpected desensitization of some oxygen-deficient triazoles upon nitration. 相似文献
27.
Zhiyuan Jiang Peng Liu Qihui Chen Hung-Jue Sue Tim Bremner Lorenzo P. DiSano 《应用聚合物科学杂志》2020,137(33):48966
Interest in developing high-performance blends for niche applications has grown significantly in efforts to meet ever-increasing harsh environment demands. In this work, four model poly(aryl-ether-ketone)/polybenzimidazole (PAEK/PBI) blends were chosen to study the influence of premixing methods, processing, and matrix polymers, on their mechanical properties. Among the model poly(ether ether ketone) (PEEK) and PBI blends, mechanical properties are greatly enhanced by melt premixing. The molding process mainly affects the matrix crystallinity, which in turn greatly influences fracture toughness of the blend. Poly(ether ketone ketone) (PEKK) and PBI blend exhibits a slightly lower tensile strength and fracture toughness than PEEK/PBI due to the differences in inherent properties of PEEK and PEKK matrices and their interfacial interaction with PBI. The processing−structure–property relationship of PAEK/PBI blends is established to help guide optimal design of high-performance polymer blends for structural applications. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48966. 相似文献
28.
Hydrolytic stability is an essential requirement for polyurethanes (PUs) that are used in highly humid and aqueous environments. In this study, hydrolysis-resistant PU elastomers (PUEs) are synthesized based on hydrophobic bio-based polyfarnesene diol (PFD), which contains unique “bottle brushes” structure (with long branched hydrocarbon side chains). The effect of hard segment (HS) content, ranging from 30 to 50%, on the morphology and properties of PUEs is investigated by Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, tensile, water absorption, and contact angle measurements. The results show that there are prominent phase separations in the synthesized PUEs. The PUEs show a three-stage degradation process and two Tg, one is at about −66 °C and the other 61 °C, which are related to the soft segment and HS, respectively. Water contact angles of PUEs increase from 98.6 to 105.2° with the increasing of PFD structural unit fraction. After being immersed in deionized water for 30 days, PUEs show no significant degradation of both tensile strength and elongation at break, and mass changes of all samples are less than 0.5%. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47673. 相似文献
29.
This study aimed to investigate the effects of brand anthropomorphism on consumer-brand relationships in a social media marketing context. We hypothesized that anthropomorphism on a brand’s Facebook fan page can strengthen the relationships between brands and consumers by yielding both social presence and a positive inference regarding the brand’s quality as a relationship partner. Our longitudinal experiment confirmed the effects of brand anthropomorphism on consumer-brand relationships on social media and the mediating role of social presence. The results suggest that when the anthropomorphized brand had relationships with consumers, a favorable attitude was shown toward the brand. Further, the participants perceived the anthropomorphized brand as a trustworthy relationship partner, giving more “Likes” for the posts from the anthropomorphized brand than those from the non-anthropomorphized brand. Further, the results confirmed that these favorable relationships were maintained even after the participants became aware of a brand transgression. 相似文献
30.
Dr. Andrija Smelcerovic Dr. Jelena Lazarevic Katarina Tomovic Marija Anastasijevic Dr. Marko Jukic Dr. Gordana Kocic Dr. Marko Anderluh 《ChemMedChem》2019,14(5):514-521
Due to uncomfortable injection regimens of peptidic agonists of glucagon-like peptide-1 receptor (GLP-1R), orally available nonpeptide positive allosteric modulators (PAMs) of GLP-1Rs are foreseen as the possible future mainstream therapy for type 2 diabetes. Herein, current GLP-1R PAMs are reviewed. Based on the effectiveness and in silico predicted physicochemical properties, pharmacokinetics, and toxicity, possible candidates for further development as oral drugs were selected. The suggestion is that GLP-1R PAMs might be used orally alone or in combination with dipeptidyl peptidase-4 (DPP-4) inhibitors, which could offer an optimal treatment option next to metformin monotherapy in type 2 diabetes mellitus, or in a wider spectrum of indications. Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects. 相似文献